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Chemotherapeutic agents and immune checkpoint inhibitors (ICIs) have been shown to activate caspase-3, which subsequently cleaves GSDME, triggering pyroptosis in melanoma cells (75, 78)

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I believe that these effects will counteract the upstream symptoms seen in Keratosis Pilaris, resulting in a regulated skin barrier, reduced inflammation, and preventing keratin accumulation in the follicular canal

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[4] Common localized effects include transient stinging, erythema, blanching, or mild edema