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In line with the earlier finding, DOX administration in this investigation markedly elevated oxidative stress by blocking Nrf2 activation and lowering endogenous antioxidant enzyme levels 84

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The imbalance of Th17/Treg and Th1/Th2 ratios is an important factor in the pathogenesis of ITP

Current treatments primarily focus on symptom management, with limited efficacy in halting or reversing disease progression

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