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The drug also distributes widely in the body (volume of distribution of 462,579 mL) and cleared at a rate that supports once-weekly administration (apparent clearance of 16,758 mL/h)

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Wells were treated with CysOx1 or CysOx 2 (50 M final concentration) and an organelle-selective dye (Invitrogen, ER-tracker red, Cat

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