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Gut microbiota in liver disease: what do we know and what do we not know

When mitochondrial iron homeostasis is disrupted, cellular iron trafficking becomes dysregulated, leading to impaired energy metabolism, excessive ROS formation, and increased vulnerability to ferroptosis (62)

Human studies have reported no adverse effects from using solutions containing 0.610.0% vitamin C or its synthetic derivatives [84]

doi: 10.1038/s41598-023-41194-2

An appropriate inflammatory response is a crucial defense mechanism, triggering tissue repair through immune modulation in response to pathogen invasion or tissue damage [7]

GSSG is then reduced back into GSH by the activity of glutathione reductase, which requires NADPH to regenerate the mitochondrial pool of GSH (reviewed in greater detail in Andreyev et al