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Induction of ferroptosis in MM cells upregulates key genes implicated in cellular stress, death, inflammation, and fatty acid metabolism, including ferritin heavy chain 1 (FTH1), HO-1, and SLC7A11

Lalani J, Rathi M, Lalan M, Misra A

[PubMed] [Google Scholar] Wu F., Minteer S

Additionally, dysregulation in the phosphoinositide 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway further accentuates the demand for glutamine, driving an accelerated flux through the tricarboxylic acid (TCA) cycle to fuel the biosynthetic requirements of rapidly proliferating cancer cells [31]