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Such metabolic rewiring towards increased aerobic glycolysis also formed the basis for -glucan-induced trained immunity of monocytes and was associated with epigenetic histone modifications and increased expression of genes involved in glycolysis triggered by the AKT-mTOR-HIF1 pathway (Cheng et al., 2014

93-105 Coplan JD et al (2021) Early life stress and the fate of kynurenine pathway metabolites