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Because of variations in NQO1 levels in normal and cancer tissues, careful consideration in preclinical studies should be given to address drug efficacy and toxicity

(2015) found a drop in GSH levels and Nernst potential (Eh) (indicating oxidative stress), an increase in 4-hydroxynonenal (4-HNE), and a decline in ovarian follicles in Gclm null female mice

10.1590/1980-220X-REEUSP-2023-0183en 52 LiZ

The ability of these precursors to release RSSH also was examined in the presence of thiols, which are likely to be present in significant concentrations under physiological conditions

eLife 8, e49248

However, other groups have shown that efficient mTORC1 suppression is necessary to avoid MZB loss 39