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A strong indication of this is the inhibition of collagen contraction by TS2/16 (ref

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10.1097/BRS.0b013e3181a0193d 114 JurgensW

These differences in apparent efficacy of NS form and in healthy individuals versus those with MetS need further confirmation

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However, certain populations are at higher risk of deficiency, including older adults, vegans and vegetarians, individuals with malabsorption disorders (such as pernicious anaemia or coeliac disease), and those taking long-term proton pump inhibitors or metformin