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10.1186/1471-2466-9-5 121 ZhangB.NiuW.XuD.LiY.LiuM.WangY.et al (2014)

Inhibitors were added at a concentration dependent on the compounds IC 50 , from 125500 M

This may explain why the brain is particularly susceptible to aggregation-related neurodegenerative diseases

The nervous system's high metabolic demands and limited regenerative capacity make it particularly vulnerable to B12 deficiency

Upon binding AGEs, these receptors activate signaling pathways such as NF-B kinase (Nuclear Factor kappa-light-chain-enhancer of activated B cells) and Mitogen-Activated Protein (MAP), increasing the production of Matrix Metalloproteinases (MMPs) and inducing heightened intracellular ROS and cytokine production