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It was well known that, under physiological conditions, the NRF2/HO-1 axis is essential for resistance to oxidative stress, and upregulation of this axis significantly suppresses the expression of NLRP3, caspase-1, and ASC, inhibits inflammasome formation, blocks GSDMD activation, and prevents the release of IL-1 and IL-18

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Their findings suggest that the oxygen atom on quercetins B ring is the primary site of electron density change, underpinning its ROS-scavenging activity

Interferon-gamma protects against cuprizone-induced demyelination

A glance at the publication volume curve reveals a consistent year-on-year increase in publications in this field