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An important remaining question is the nature of the sulphated signal released by ASJ
The resulting injection delivers both compounds subcutaneously in a single weekly dose, eliminating the need for separate administrations
Approximately 0.5% of the general population are apoE2/E2 homozygotes, but only a small minority of these individuals develop FDBL
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Importantly, all cis- and trans- regulatory elements mostly exert their effects not only on the apoC1 gene alone but on the whole ApoE/C1/C1/C2/C4 gene cluster [23, 24, 26,27,28]
