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For individuals with BMI above 30 or BMI above 27 with comorbidities, FDA-approved GLP-1 receptor agonists (semaglutide, tirzepatide) have far stronger evidence and produce dramatically greater weight loss

The above procedure was repeated with inhibitor concentrations spanning 0.3 60 M to determine the effective concentration (EC 50 ) required to inhibit 50% NNMT activity in cultured adipocytes

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