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Research on animals suggests that Lrrk2 p.G2019S mice had more severe colitis than controls, which results in decreased motor function and death of dopaminergic neurons (97)

The timeline is gradual: better sleep and energy at 4 weeks, less bloating and improved recovery at 8 weeks, measurable body composition changes by 12 weeks

Neurological Symptoms Deficient serum folate concentrations can lead to neurological symptoms

Gastrointestinal effects: the main titration bottleneck Nausea, diarrhea, constipation, and vomiting run around 40 to 44% overall, dose-dependent in how many people report them but mild-dominant in severity: severe events stay at or below about 1.7% in any category even at the top dose. In the obesity program the by-dose rates run nausea 25/29/28%, diarrhea 19/21/23%, and vomiting 8/11/13% at 5/10/15 mg. They concentrate during escalation and ease with time on a held dose

[DOI] [PMC free article] [PubMed] [Google Scholar] Ley K

Intranasal Insulin Reduces White Matter Hyperintensity Progression in Association with Improvements in Cognition and CSF Biomarker Profiles in Mild Cognitive Impairment and Alzheimers Disease