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Resistance It is known from a disease called diabetes mellitus, that there can be resistance to the actions of the hormone insulin the main regulator of blood glucose concentrations in many individuals

35 There is also compelling evidence that vitamin B 12 deficiency occurs frequently during pregnancy, 2 6 7 and case studies have demonstrated harmful effects of severe vitamin B 12 deficiency on the developing infant brain

Normally, humans maintain a large vitamin B 12 reserve, which can last two to five years even in the presence of severe malab-sorption

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Mood disorders such as depression and bipolar are very much associated with B12 deficiencies (7, 8)

CH was supported by the MRC Human Genetics Unit quinquennial programme grant QTL in Health and Disease (MC_UU_00007/10)