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Wang and colleagues demonstrated that hypoxic conditions (3% O 2 ) in rat MSC cultures increased proliferation by upregulating the mitogen-activated protein kinase (p38 MAPK) signaling pathway and inducing the nuclear translocation of hypoxia-inducible factor (HIF)-1a, key factors for cell proliferation, and the promotion ofdopaminergic neuronal differentiation

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NACP/alph-synuclein-positive filamentous inclusions in astrocytes and oligodendrocytes of Parkinson's disease brains

Atherosclerosis (2020) 296:5965

Response of IGF1 Signaling Pathway to Radiation Heavy-ion 56 Fe radiation led to increased serum IGF1 levels 2 months after exposure and decreased IGFBP-3 levels in serum along with increased IGF1R in tissues (Suman et al., 2016)