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It has been estimated that approximately one-third of AAS users may develop a dependence syndrome, characterized by withdrawal symptoms and continued use despite awareness of negative health or social consequences (62)

Shi J, Xu J, Chen YE, Li JS, Cui Y, et al

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Previous studies have shown that enhanced binding of IGF-1 to IGF-1R activates the ERK pathway, promoting collagen synthesis (127)

Yamada Y, Akita H, Kamiya H, Kogure K, Yamamoto T, Shinohara Y, Yamashita K, Kobayashi H, Kikuchi H, Harashima H (2008) MITO-Porter: a liposome-based carrier system for delivery of macromolecules into mitochondria via membrane fusion