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A more precise definition of target engagement and dose-response relationships will be important to maximize benefit while minimizing potential risks associated with NRF2 overactivation (Jin et al., 2025
10.1007/s11655-016-2407-3 107 LiH.LiD.MaZ.QianZ.KangX.JinX.et al (2018)
No findings suggest clinical relevance, therapeutic intent, or suitability for human or veterinary use
The amlodipine-treated group exhibited normalization of all diastolic parameters but one (IVRT) (Figure 2D)
Sheng, J
Because its topical rather than systemic, the risk profile differs from an injectable
