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However, TMA production was decoupled from l-carnitine utilization and was only produced when both E

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Our findings lead us to conclude that these immunogenic peptides have the ability to generate clonally amplified CD8 + T cells against the tumour, and could therefore be used towards the generation of an anti-tumour vaccine

Basically, the superoxide free radical (for example from leak from complex I in mitochondria and biochemically by reactions involving xanthine/xanthine oxidase or NADPH oxidase) and nitric oxide [NO, formed by catalytic action of nitric oxide synthase (NOS) on arginine] react in a radical-radical recombination to form peroxynitrite, a nonradical (38, 39)