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These vitamins are necessary for the proper functioning of enzymes involved in the methylation process, and deficiencies can contribute to imbalances in the methylation cycle

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Mechanism of action of antioxidant Antioxidants obtained from eco-friendly sources have demonstrated extraordinary efficacy in neutralizing free radicals, namely the DPPH radical, also known as DPPH

[DOI] Chaput M., Simon J

doi: 10.3389/fnagi.2025.1737001 Received 31 October 2025 Revised 13 December 2025 Accepted 17 December 2025 Published 10 February 2026 Volume 17 - 2025 Edited by Slawomir Jakiela, Warsaw University of Life Sciences, Poland Reviewed by Sajad Fakhri, Kermanshah University of Medical Sciences, Iran Emre Adigzel, Karamanolu Mehmetbey University, Trkiye Updates Copyright 2026 Guo and Chi

Mechanistically, we reveal that VRK2 inhibition disrupts endoplasmic reticulum (ER)-to-Golgi trafficking of SLC7A11, consequently diminishing GSH biosynthesis and predisposing PC cells to ferroptosis