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L.JanelN

Birdsall TC (August 1998). 5-Hydroxytryptophan: a clinically-effectiveserotonin precursor. Alternative Medicine Review: a Journal of ClinicalTherapeutic 3 (4): 27180. PMID 9727088. Retrieved 2009-07-30.Turner EH, Loftis JM, Blackwell AD. Serotonin a la carte: supplementationwith the serotonin precursor 5-hydroxytryptophan. Pharmacol Ther. 2006Mar;109(3):325-38. Epub 2005 Jul 14.Izumi T, Iwamoto N, Kitaichi Y, Kato A, Inoue T, Koyama T. (2006).Effects of co-administration of a selective serotonin reuptake inhibitorand monoamine oxidase inhibitors on 5-HT-related behavior in rats. Eur JPharmacol. 532 (3): 258264. DOI:10.1016/j.ejphar.2005.12.075
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2017;7:e1171

Subsequently, p53 (pro-apoptotic gene) will be activated in PtDNA complex mediated DNA damage, and apoptosis induced by activated p53 is in turn repressed by overexpressed Bcl-2 gene, which in turn indirectly inhibits Bcl-2 expression through transcriptional activation of BAX, a pro-apoptotic factor
