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Dysfunction of the respiratory epithelium (ciliary dyskinesia) and depletion or dysfunction of immune mediator cells and molecules, including immunoglobulin (Ig) G and IgE, complement (due to mannose- binding lectin deficiency), cathelicidins (antimicrobial peptides), toll-like receptors (which are key to pathogen recognition), neutrophils, macrophages, and T and B lymphocytes, may permit microbial persistence, excessive inflammatory response to infection and failure of mucociliary clearance

Metformin decreases IL-22 secretion to suppress tumor growth in an orthotopic mouse model of hepatocellular carcinoma

Glutamate in cell medium was detected by using Amplex Red Glutamic Acid/Glutamate Oxidase Assay kit (# A-12221, Thermo Fisher) as per the manufacturers instructions