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Therefore, localized administration methods, such as intra-articular injection or combination with sustained-release carriers, are considered more feasible and safer clinical translation pathways

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JAK inhibitors represent another class of targeted therapy, but like anti-TNF agents, they come with significant immunosuppressive effects

and iii) identification of inter-individual-variability in NAPQI production and consequently identify individuals or populations with underlying predispositions ( e.g

Fath S, Bauer AP, Liss M et al (2011) Multiparameter RNA and codon optimization: A standardized tool to assess and enhance autologous mammalian gene expression