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These studies have focused primarily on early life stress or trauma, but gene by environment interaction studies are being expanded to include protective factors such as social support and intervention, as well as genes that increase resilience to depression 181,184

NHS and NICE-recommended weight management approaches including structured lifestyle interventions, behavioural support, and where appropriate, licensed pharmacological treatments such as orlistat or GLP-1 receptor agonists have a substantially stronger evidence base than L-carnitine supplements

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