5-amino-1mq human clinical trial (5mg & 50mg) for Research 5-Amino-1MQ – 10MG – Ascension

William Silverstein of the University of Toronto

showed a 32% drop in chronic low back pain with B12 injections over a two-week period, compared to placebo (it is worth noting that the patients had no form of blood test to assess B12 status)

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Rather than directly supplying NAD+ precursors (like NMN or NR), it works by blocking an enzyme that consumes nicotinamide, theoretically preserving the substrate pool for endogenous NAD+ production

The preclinical data is generally consistent and encouraging

others run continuous daily for a fixed block