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639 Together, the NAMPT enhancers, P7C3 and SBI-797812, warrant further study for the clinical treatment of neuron related diseases

doi: 10.1021/tx2003596

(1976) crustacean water flea 22 7.0- 154 stat, closed 48 h EC50 f 0.093 Randall & (Daphnia magna) 8.2 Knopp (1980) crustacean water flea 22 7.4- 6-9 173 stat, closed 48 h LC 50 0.083 LeBlanc (Daphnia magna) 9.4 (1980) fish harlequin fish 20 7.2 20 flow, open 48 h LC 50 0.06 Alabaster (Rasbora (1969) heteromorpha) Table 12 (contd)

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However, human epidemiological evidence for transgenerational effects remains limited, primarily due to the extended timeframes required for multigenerational studies and the practical challenges of maintaining long-term cohorts across decades ( Low-Dose Chronic Exposure Effects Present Assessment Challenges EEDs frequently exhibit non-monotonic dose-response (NMDR) patterns, where low-dose chronic exposure may produce more pronounced biological effects than acute high-dose exposure