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Historical Background and Scientific Context Scientific interest in metabolic regulatory enzymes expanded rapidly during the late twentieth century as molecular biology techniques improved

doi: 10.1016/j.drudis.2007.08.010

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Certain populations face higher deficiency risk: vegetarians and vegans (B12 is primarily found in animal products), adults over 50 (decreased stomach acid reduces B12 absorption), individuals with digestive disorders like Crohn's disease or celiac disease, and those taking medications like metformin or proton pump inhibitors

10.1038/s41598-022-10476-6 139 TeperinoR.SchoonjansK.AuwerxJ

Promotes Metabolic Flexibility Helps the body switch efficiently between carbohydrate and fat energy sources