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If the underlying issue isnt addressed - whether its inflammation, structural imbalance, or nervous system dysregulation - results may be temporary or minimal

Among experts, a clinically meaningful change in ALSFRS-R in clinical trials would be a reduction of about 20% in the slope of rate of decline [34]

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By interacting directly with MAPKs, including c-Jun N-terminal kinase 1 (JNK1) and apoptosis signal-regulating kinase 1 (ASK1), GSTs bind the ligand in a complex structure, preventing interactions with their downstream targets [74]

Gnanaraj J, Parnes A, Francis CW, Go RS, Takemoto CM, Hashmi SK

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