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BCAAs can provide an anaplerotic substrate in some tissues (Fig

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Additionally, metabolic dysregulation of metal ions such as iron, copper, and manganese in the brain can catalyze Fenton reactions, generating reactive oxygen species that exacerbate OS and protein misfolding [31]

[DOI] [PubMed] [Google Scholar] 99.Luo N, Marcelin G, Liu SM, Schwartz G, Chua S., Jr Neuropeptide Y and agouti-related peptide mediate complementary functions of hyperphagia and reduced energy expenditure in leptin receptor deficiency

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For example, dietary methionine restriction (MR) in combination with PD-1 blockade increases the abundance of tumor-infiltrating CD8+ T cells and enhances granzyme B expression