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In einer 26-wchigen, dosisfindenden Phase-II-Studie erhielten 706 Erwachsene mit Adipositas oder bergewicht Cagrilintid in fnf Dosierungen (0,34,5 mg SC wchentlich), Placebo oder Liraglutid 3,0 mg, jeweils zusammen mit einer Lebensstilnderung

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At a later stage, MET is predominantly pre-synaptic, reflecting a dynamic regulation of MET expression depending on the post-natal age of the examined mice ( FIGURE 2 The pMET protein levels peak at P7P14 in the neocortex, a period corresponding to synaptogenesis and dendritic outgrowth, and are downregulated during the 3rd post-natal week, between P14 and P17, when pruning and functional synapse maturation occur ( Rhesus monkey) (Judson et al., 2011) reveals a similar temporal expression pattern of MET as in rodents, with peak levels corresponding to the same periods detected in mice and rats

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[DOI] [PMC free article] [PubMed] [Google Scholar] 246.Littlejohn G., Guymer E