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Rachman H, Kim N, Ulrichs T, Baumann S, Pradl L, Eddine AN, et al

This leads to the accumulation of unfolded or misfolded proteins in the endoplasmic reticulum lumen, initiating the endoplasmic reticulum stress response and triggering the unfolded protein response (UPR) (Oakes and Papa, 2015)

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HGF consists of seven domains: an amino terminal domain, a dimerization-linker domain, four kringle domains (Kl - 4), and a serine proteinase homology (SPH) domain

The traditional method has been used on the body for thousands of years in Chinese medicine

However, contradictory findings were obtained in a recent study which concluded that mutant TDP-43 A315T does not impair mitochondrial bioenergetics in vitro and in vivo (Kawamata et al., 2017)