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Description
In research settings it is primarily investigated for lipid metabolism, adipose tissue regulation, and energy homeostasis
It also regulates glucose metabolism, making it suitable for diabetic and non-diabetic individuals
The synthesis of the diphthamide residue found on His715 in human translation elongation factor eEF2 requires a methylation step involving SAM as the methyl donor
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It activated the SLC7A11/GPX4 signaling pathway, upregulated GSH-Px and GSH expression, decreased MDA and ferroptosis levels, and inhibited lipid peroxidation and ferroptosis in the cerebral cortex, thereby improving motor function, balance, and neurological deficits in the rats
[DOI] [PMC free article] [PubMed] [Google Scholar] Zhang J, Chen S, Li Y, Di B, Zhang J, Liu Y
