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4 Furthermore, reduced glutathione concentration and/or a disproportionate ratio of GSH:GSSG has been associated with a number of diseases, including cancer, human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS), hepatitis, type 2 diabetes, Parkinson's disease, and cystic fibrosis

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therefore, depolarization and hyperpolarization of the membrane potential either diminishes or increases the release of GSH, respectively [97]