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(R)-2-hydroxyglutarate inhibits KDM5 histone lysine demethylases to drive transformation in IDH-mutant cancers

Am J Physiol Regul Integr Comp Physiol 305(7):R804R810 Poonam D, Vinay CS, Gautam P (2005) Cyclo-oxygenase-2 expression and prostaglandin E2 production in experimental chronic gastric ulcer healing

Rochette L, et al

Khan OF, Zaia EW, Yin H, Bogorad RL, Pelet JM, Webber MJ (2014) Ionizable amphiphilic dendrimer-based nanomaterials with alkyl-chain-substituted amines for tunable siRNA delivery to the liver endothelium in vivo

Sandstrom et al., 2017), solitary nucleus, and catecholaminergic neurons in the pituitary-adrenal system (Edmonds and Edwards, 1996), all of which subsequently decrease the dopamine concentration in the brain (Barbeau et al., Studies have indicated that PQ dopaminergic neurotoxicity is associated with increased cellular oxidative stress and neuroinflammation, which induces -synuclein aggregation and impairs neurons (Manning-Bog et al., 2002

It was originally identified as a fragment derived from a larger protein found in human gastric juice, which sparked early scientific interest due to its unusual stability and biological activity under experimental conditions