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Targeted microbiota interventions have a more predictable safety profile and higher translational significance [124]

In all three studies, alprazolam was superior to placebo on a variable defined as "the number of patients with zero panic attacks" (range, 37 to 83% met this criterion), as well as on a global improvement score

[118] documented Met5-enkephalin-Arg 6-Phe7 binding to non-opioid receptors as did Webster et al

doi: 10.1016/j.bbagen.2013.04.016