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Individuals with B12 sensitivity, certain medical conditions, or allergies should consult their provider before starting treatment.

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One study showed that over 50% of patients seen in wound care clinics would have been excluded from 15 of 17 reviewed trials, and even after relaxing criteria, 2550% would still have been ineligible

doi:10.1136/bmjopen-2018-027925 Mehta ND, Haroon E, Xu X, Woolwine BJ, Li Z, Felger JC

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doi: 10.3389/fimmu.2025.1549865 Received 22 December 2024 Accepted 14 July 2025 Published 30 July 2025 Volume 16 - 2025 Edited by Mariusz Cyco, Medical University of Silesia, Poland Reviewed by Cuncai Guo, Washington University in St