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Description
Physiology-Cell Physiology 289 (2), C455C461
10.1016/j.bbi.2016.03.020
Injections are subcutaneous (SQ) using an insulin syringe, administered at home after the first clinic injection
IL-1 and TNF- stimulate chondrocytes and synovial cells to secrete MMP-1, MMP-3, and MMP-13, which degrade collagen and proteoglycans in the cartilage matrix, worsening cartilage damage (150, 151)
This normalization was validated by actual colony counts to confirm that each sample contained 1 10 8 CFU/mL before RNA extraction
To date, clinical development in this field remains at an early stage, and the available efficacy data are limited and inconsistent across compounds, indications, and trial designs
