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Peptides occur naturally in the body but break down quickly after serving their purpose

Metabolite identity was established using a combination of an in-house metabolite library developed using pure purchased standards, the NIST library, and the Fiehn library

doi: 10.1080/00071660903401540

One study found as many as 30% of patients hospitalized for depression were deficient in vitamin B 12 (96)

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General recommendation for prevention and treatment of critically ill patients with AKI are based on: (1) correction of hypovolemia using isotonic crystalloids with avoidance of hyperhydration, (2) regular monitoring of ions (chloride) and acid base-balance with adequate correction when chloride rich solutions are used, (3) use of vasopressor norepinephrine to maintain mean arterial pressure 6570 mmHg, (4) use of diuretic agent to avoid fluid overload and preserve diuresis if needed, (5) tight control of serum glucose, (6) therapeutic drug monitoring in initiation of therapy with highly nephrotoxic antimicrobials (e.g., vancomycin, gentamicin), (7) initiation of renal replacement therapy (RRT) according to the clinical picture or laboratory findings, usually in stage 2 or 3 according to KDIGO [1,137]