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2.3.3 Sphingosine-1-phosphate receptor 2: potential crosstalk with conjugated bile acids in TIME Beyond receptors primarily sensing unconjugated or secondary BAs, the G protein-coupled receptor Sphingosine-1-Phosphate Receptor 2 (S1PR2) represents another signaling node potentially linking BA metabolism to the TIME, primarily through interactions with conjugated bile acids (CBAs) (103)

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And specific genes represent a large fraction of genes in PAV regions (ranging from 69.1% to 72.9%) (Supplementary Fig

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Its usually from toothpaste or water with high fluoride levels

doi: 10.1016/j.heares.2012.12.014