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Hur 2015), and a growing body of laboratory, animal, and human research indicates metformin may normalize the disturbed microbial balance associated with abnormal glucose metabolism (Pryor 2015

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Loss of the NC population is associated with the early development of IVD disease [58], and thus restoring the NC population may help to delay or even reverse IVD degeneration [14]

According to the up-and-down test (Sunderam, 2004), if the fish survives after 24 h, they will be exposed to a concentration that is 1.3 times higher and vice versa