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B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation

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doi: 10.1016/j.biopha.2020.111119

The authors reported that hnRNP A2 LCD tyrosine phosphorylation can alter phase separation and inhibit the formation of hnRNP A2 aggregation in vitro and in vivo, as well as disease ALS/FTD-associated mutants (hnRNP A2-D290V) 92