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Loss of TTLL6 increased inner dynein armdriven MT sliding in the absence of outer dynein arms, demonstrating that tubulin glutamylation functions as a negative regulator of inner dynein arm activity and thereby fine-tunes ciliary waveform and beat frequency [52]

Covalent/irreversible inhibitors target the redox/catalytic apparatus of TGR with almost no recognition elements that give affinity and selectivity for TGR over off-targets and the cellular redox apparatus resulting in undesirable cross-reactions and low specificity in vivo 25

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a study of 400 cases