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Human studies have shown that long-term Met restriction is well-tolerated with minimal adverse effects

Next, the increased GSH system modelled how the behaviour of the system might change with more GSH available, produced by GshF introduced via our plasmid

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This pathway is hyperactivated in NF1-related tumours, and inhibition of MAPK kinase (MEK) was effective at controlling tumour size in a mouse model of NF1

In the body, glutathione exists in two states: reduced (GSH) and oxidized (GSSG)