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Superoxide radical inhibits catalase

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Neurons were treated with tetrodotoxin, picrotoxin, and strychnine to suppress action potential, GABA-dependent inhibition, and glycine-dependent inhibition

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Whereas, several studies have demonstrated that high-dose and long-term administration of artemisinin-based drugs has gastrointestinal, neurotoxic, and cardiotoxic effects in experimental animals (e.g., rhesus monkeys, rats, and dogs), and the most common adverse effects are nausea, vomiting, and dizziness (Li et al., 2019

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