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Shah et al., 2018), and 12-LOX is indispensable for p53-mediated ferroptosis (Chu et al., 2019)

This process provides the material and energy basis for the rapid proliferation of cancer cells and maintains redox homeostasis in tumor cells

10.3390/cells12060936 46 ChaudhariN.TalwarP.ParimisettyA.Lefebvre d'HellencourtC.RavananP

In a study by Momma et al., the view that VA is produced only by gut microbes was broken by co-incubating human serum, HUVEC cell lysate, or PON-transfected HEK293FT cell lysate with 3,4-DHPV (1500 M) at 37C, confirming that PON1/3 in serum can enzymatically hydrolyze 3,4-DHPV to VA by enzymatic hydrolysis, forming a new pathway of host metabolism (Momma et al., 2023)

Gilbert J, Lekstrom-Himes J, Donaldson D, et al
