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It means that the efficacy of monotherapy could be offset by other signaling pathways

Best Practices Recommendations for Microtransitions in CareAn Emerging Classification of Care Transitions: A Consensus Statement

After a mean of 9.3 years, the recurrence of postoperative curvature had increased from 0% after a mean of 38 months (1873 months) to 23.7%, post-op erectile dysfunction increased from 3.0% to 39.5%, penile shortening from 0.0% to 65.8%, and impairment of penile sensitivity from 3% to 31.4%

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doi: 10.1080/003655202320378220, PMID: [DOI] [PubMed] [Google Scholar] 37

Visual risk factors for crash involvement in older drivers with cataract