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Additionally, the gene contains two functional polymorphisms in the coding sequence: the first one, a nonsynonymous substitution (R248W) reduces hIDO2 catalytic activity by ~90% and the second one, a premature stop codon (Y359X), completely abolishes it

Interaction assessments based on receptor binding affinity, signaling pathway analysis, and published preclinical data

10.1016/j.molcel.2015.01.027 7 BaierP

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Some researchers have pointed to autoimmune overlap, where people with autoimmune thyroid conditions like Hashimotos thyroiditis are also more likely to have pernicious anemia or low B12 due to shared autoimmune mechanisms

Very helpful I really like how I feel in these frosty days