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Similarly, recruitment of participants with severe hepatic impairment into the hepatic impairment study was challenging and, despite a third study site being added and the recruitment period being prolonged, it was not possible to complete recruitment of seven participants into the severe hepatic impairment group

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Curr Drug Metab (2011) 12:66778

Citrate metabolism controls the senescent microenvironment via the remodeling of pro-inflammatory enhancers

Keywords: acetaminophen, autism spectrum disorder, evidence-based medicine, health communication, narrative review, neurodevelopmental disorders, paracetamol, pregnancy, risk communication, shared decision-making Abbreviations ACOG: American College of Obstetricians and Gynecologists ADHD: Attention-Deficit/Hyperactivity Disorder CB1: Cannabinoid Receptor Type 1 CDC: Centers for Disease Control and Prevention CI: Confidence Interval DNA: Deoxyribonucleic Acid EMA: European Medicines Agency FACT: Evidence Suggests Link between Acetaminophen, Autism FDA: Food and Drug Administration HHS: Health and Human Services HR: Hazard Ratio MMR: Measles, Mumps, and Rubella NAPQI: NAcetylPBenzoquinone Imine OS: Oxidative Stress RCOG: Royal College of Obstetricians and Gynaecologists SMFM: Society for Maternal-Fetal Medicine Introduction On September 22, 2025, a United States governmental announcement indicated that the Food and Drug Administration (FDA) would modify labelling for paracetamol (acetaminophen, branded as Tylenol in the United States) to warn of possible associations with autism spectrum disorder when used during pregnancy (Horton, 2025[53]