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In experimental models of other neuroinflammatory conditions such as multiple sclerosis and stroke, pMHC/neuroantigen peptide constructs have been shown to successfully: 1) repair myelin and axonal damage back to baseline levels prior to disease induction, 2) reduce numbers of infiltrating inflammatory cells in the central nervous system, 3) reduce expression of intracellular adhesion molecule and vascular adhesion molecule on vascular endothelial cells, likely contributing to the reduction in infiltrating inflammatory cells, 4) reduce levels of inflammatory cytokines, chemokines, and chemokine receptors, 5) reduce infarct size following middle cerebral artery occlusion, and 6) prevent or reverse clinical disease signs [38], [39], [40], [41]

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These cells are essential in fighting off infections and keeping your immune system in good working order

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