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11 , e1004219 (2015)

CYP3A4 mediated N-demethylation to norhydrocodone is the primary metabolic pathway of hydrocodone with a lower contribution from CYP2D6 mediated O-demethylation to hydromorphone

[DOI] [PMC free article] [PubMed] [Google Scholar] 145.Huang L, Deng M, He Y, Lu S, Ma R, Fang Y
Zhou et al., 2022 and AChE activity (Olofinnade et al., 2021)

In addition, local necrosis was evident from the centralized globular hyperintense signal in both coronal and transverse images

Since glutathione is used in the body for numerous other functions, it can get depleted quickly, thus the need for reuse
