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Huperzine a alleviates oxidative glutamate toxicity in hippocampal HT22 cells via activating BDNF/TrkB-dependent PI3K/Akt/mTOR signaling pathway

These enzymes are instrumental in the breakdown of the extracellular matrix (ECM), the penetration of basement membranes, the processes of endocytosis and exocytosis, and the promotion of further angiogenesis

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Conversely, the mitochondrial damage and calcium homeostasis imbalance triggered by NLRP3 activation further exacerbate mtROS production, creating a positive feedback amplification loop